Meditopic® StriCell

StriCell stretch mark cream is made with liposomed stem cells of the plant, Centella Asiatica. Centella Asiatica has been shown in clinical studies to improve the appearance of stretch marks (Striae distensae), including stretch mark discoloration and skin surface texture through preventative use as well as usage after stretch marks first appear.

Stretch Marks: Changes in the Appearance of the Skin
Stretch marks are common by the end of pregnancy, occurring in most women. And while many women report that their stretch marks later shrink and fade, they rarely report them going away completely. Stretch marks are classified by genus (men and women) and according to their distribution (horizontal and vertical). The type and appearance of stretch marks depends largely on genetics, skin color, age, and health of a person’s skin. There are two primary types of stretch marks: Striaerubra (red stretch marks) and Striaealba (white stretch marks). Striaerubra are typically wider than other forms of striae distensae, and can be observed in both in men and women. Striaealba, are generally longer and more narrow and found most often among currently and recently pregnant women.

There are a number of creams on the market that claim to eliminate stretch marks once they have developed, but few have reliable supporting evidence or clinical studies to support their claims. We do know that stretch marks are sometimes reduced in certain women through the application of moisturizing lotions, but it remains unclear what, if any ingredients in these moisturizing creams bring special benefit (though some evidence seems to suggest Shea Butter is effective for some women). What is largely unknown is why some women see reduced scaring from the use of moisturizers while others do not.

Liposomal preparations of Centella Asiatica stem cells, like Meditopic StriCell, have been evaluated to effectively treat both preventative and later-development stretch marks (through in vivo tests), in a scientifically significant percentage of women who use them (see level-2 evidence of positive test results), and have been found to improve skin’s overall appearance, including a return to natural coloration and skin texture.

What are Stem Cells?
Stem cells are non-programmed and undifferentiated cells found in multi cellular organisms that have a large capacity of self-renewal. They are able to replenish themselves through mitotic division into two identical daughter cells and also have the unique ability to differentiate and become specialized cells with specific functions. The behaviour and characteristics of stem cells depends on the signals from the neighboring environment and epigenetic factors, which induce changes in gene expression. Their special properties provide stem cells with a great potential for regenerative medicine and cosmetic applications. In the case of Centella Asiatica, it is suggested that stem cells stimulate fibroblasts and have an antagonistic effect against glucocorticoids, steroidal hormones responsible for aspects of skin and tissue development.

Clinical Evaluation & Efficacy
MEDITOPIC’s StriCell in vitro efficacy has been evaluated in active epidermal stem cells and tissues. The effect of the StriCell on the proliferative activity of the epidermal stem cells was studied by identification of stem cell markers Keratin 10 (expressed by all viable suprabasal keratinocytes in normal human epidermis, becoming a specific marker for differenciated keratinocytes) and Ki67 (marker of identity of pluripotency of epidermal stem cells).

Effect Of MeditopicStriCell In The Treatment Of Striae Distensae

StriCell, formulated specifically as a nourishing anti-stretch mark agent, is a novel source of active ingredients (including Centella Asiatica) for skin renovation. Evaluated by dermatologists in a in vivo test carried out on a sample of women between 35-60 years. StriCell improved the general look of the stretch marks (+32%), reduced the intensity of their color (-31%) and improved the skin surface roughness (-35%) in 28 days. For a significant percentage of volunteers, the product was judged to improve stretch marks appearance, firmness and elasticity of skin. Volunteers stated that skin looked brighter, smoother, softer and more comfortable. 75% of volunteers expressed that the overall look of the stretch marks had improved. 70% of volunteers reported that the color of their stretch marks had returned to a more nature appearance.

Source: Women (35-60 y/o), self-reported evaluations conducted by dermatologists, of StriCell usage, applied twice daily to buttocks and thighs.

Plant stem cell liposomal complex & protective effects on epidermal stem cells

In 1991, a double-blind test of 100 volunteers published in the International Journal of Cosmetic Science found that Centella Asiatic extract could prevent the development of stretch marks. In 2008, the Cochrane Collaboration performed a review of those tests, and came to the conclusion that the Centella Asiatic extract study was one of the only valid studies ever conducted on stretch mark prevention—and that Centella asiatica is the active ingredient responsible for the changes observed.

If you are interested in carrying StriCell in your clinic, spa, salon, or practice, contact us.